Journal: Pharmaceuticals

Article Title: Solubility of Poorly Soluble Drugs in Phosphatidylcholine-Based Drug Delivery Systems: Comparison of the Loading Capacity in the Bulk Formulation and Its Dispersed State

doi: 10.3390/ph17030400

Figure Lengend Snippet: ( a ) Dissolved concentrations of different drugs (%) in Mi50P50 and Mi30P70 as determined through the macroscopic and microscopic detections of drug crystals in the bulk formulation and ( b ) dissolved concentrations (%) of cannabidiol after taking into account the dispersion experiments in phosphate buffer. The formulations were loaded at 23 °C via dual centrifugation. The horizontal lines in the bars indicate which concentrations were prepared. The area above this concentration is shown in red if drug crystals were visible in the bulk formulation ( a ) or pellet ( b ). If no drug crystals were detected, the area below this concentration is shown in green. The numbers above the bars indicate the minimum solubility. The true solubility lies between the investigated concentrations in the grey hatched area. The formulations were examined during a storage period of 18 weeks. For comparison, the results after 1 and 4–6 weeks (numbers below the bars) are shown. No changes were observed after this time. * Repeat tests with artemether showed slightly different minimum solubilities (see text).

Article Snippet: The vials were flushed with nitrogen and incubated on a horizontal shaker (Vibrax VXR basic, IKA-Werke GmbH & Co. KG, Staufen, Germany) at 20 °C in a climatic room.

Techniques: Formulation, Dispersion, Centrifugation, Concentration Assay, Solubility, Comparison

Journal: Pharmaceuticals

Article Title: Solubility of Poorly Soluble Drugs in Phosphatidylcholine-Based Drug Delivery Systems: Comparison of the Loading Capacity in the Bulk Formulation and Its Dispersed State

doi: 10.3390/ph17030400

Figure Lengend Snippet: Dissolved concentrations (%) of different drugs in Mi50P50 and Mi30P70 determined by loading at 65 °C. The formulations were checked macroscopically and microscopically for drug crystals in the bulk formulation. The prepared concentrations are indicated by the horizontal lines in the bars. If drug crystals were visible, the area above this concentration is shown in red. If no drug crystals were detected, the area below this concentration is shown in green. The area in between is hatched in grey. Formulations containing clofazimine, fenofibrate and cannabidiol were examined during a storage period of 18 weeks, whereas formulations containing artemether were examined during a storage period of 12 weeks. After 9 weeks, no changes were observed. * For Mi30P70 with artemether, crystals were found in the mixtures with 33.3, 28.6 and 16.7%, whereas no crystals were visible in formulations with a concentration below 13.0% and with 23.1%.

Article Snippet: The vials were flushed with nitrogen and incubated on a horizontal shaker (Vibrax VXR basic, IKA-Werke GmbH & Co. KG, Staufen, Germany) at 20 °C in a climatic room.

Techniques: Formulation, Concentration Assay